High prevalence of Arginine to Glutamine Substitution at 98, 141 and 162 positions in Troponin I (<it>TNNI3</it>) associated with hypertrophic cardiomyopathy among Indians

• Автори: Rani Deepa (Автор), Nallari Pratibha (Автор), Priyamvada Singh (Автор), Narasimhan Calambur (Автор), Singh Lalji (Автор), Thangaraj Kumarasamy (Автор)
• Формат: Книга
• Опубліковано: BMC, 2012-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Troponin I (<it>TNNI3</it>) is the inhibitory subunit of the thin filament regulatory complex Troponin, which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Mutations (2-7%) in this gene had be...