Protease-Triggered Release of Stabilized CXCL12 from Coated Scaffolds in an Ex Vivo Wound Model

• Main Authors: Sabrina Spiller (Author), Tom Wippold (Author), Kathrin Bellmann-Sickert (Author), Sandra Franz (Author), Anja Saalbach (Author), Ulf Anderegg (Author), Annette G. Beck-Sickinger (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biomaterials are designed to improve impaired healing of injured tissue. To accomplish better cell integration, we suggest to coat biomaterial surfaces with bio-functional proteins. Here, a mussel-derived surface-binding peptide is used and coupled to CXCL12 (stromal cell-derived factor 1α), a chemo...