In Vitro Anticancer Activity Screening of Novel Fused Thiophene Derivatives as VEGFR-2/AKT Dual Inhibitors and Apoptosis Inducers

• Main Authors: Rana M. Abdelnaby (Author), Afaf A. El-Malah (Author), Rasha R. FakhrEldeen (Author), Marwa M. Saeed (Author), Rania I. Nadeem (Author), Nancy S. Younis (Author), Hanaa M. Abdel-Rahman (Author), Nehad M. El-Dydamony (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein kinases are seen as promising targets in controlling cell proliferation and survival in treating cancer where fused thiophene synthon was utilized in many kinase inhibitors approved by the FDA. Accordingly, this work focused on adopting fused thienopyrrole and pyrrolothienopyrimidine scaffol...