First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator

First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator

Abstract Soluble guanylate cyclase (sGC) and its product, cyclic guanosine monophosphate, play a role in learning and memory formation. Zagociguat (CY6463) is a novel stimulator of sGC being developed for the treatment of neurodegenerative disease. Single zagociguat doses of 0.3, 1, 3, 10, 20, 30, a...

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Main Authors: Sebastiaan J. W. vanKraaij (Author), Pim Gal (Author), Laura G. J. M. Borghans (Author), Erica S. Klaassen (Author), Francis Dijkstra (Author), Christopher Winrow (Author), Chad Glasser (Author), Geert Jan Groeneveld (Author)
Format: Book
Published: Wiley, 2023-08-01T00:00:00Z.
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