Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

• Main Authors: Fabrice Pagniez (Author), Nicolas Lebouvier (Author), Young Min Na (Author), Isabelle Ourliac-Garnier (Author), Carine Picot (Author), Marc Le Borgne (Author), Patrice Le Pape (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(2-(2,4-Dichlorophenyl)-3-(1H-indol-1-yl)-1-(1,2,4-1H-triazol-1-yl)propan-2-ol (8 g), a new 1,2,4-triazole-indole hybrid molecule, showed a broad-spectrum activity against Candida, particularly against low fluconazole-susceptible species. Its activity was higher than fluconazole and similar to voric...