Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft

• Main Authors: Zhang Anli (Author), Shen Guodong (Author), Zhao Ting (Author), Zhang Guihong (Author), Liu Jing (Author), Song Lihua (Author), Wei Wei (Author), Bing Ling (Author), Wu Zhengsheng (Author), Wu Qiang (Author)
• Format: Book
• Published: BMC, 2010-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>chA21 is a novel tumor-inhibitory antibody which recognized subdomain I of HER2 extracellular domain with an epitope distinct from other HER2 antibodies. Previously, we demonstrated that chA21 inhibits human ovarian carcinoma cell li...