Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss

• Main Authors: Xiaochen Sun (Author), Chenxi Zhang (Author), Huan Guo (Author), Jiao Chen (Author), Yali Tao (Author), Fuxiao Wang (Author), Xixi Lin (Author), Qian Liu (Author), Li Su (Author), An Qin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteolytic bone disease is characterized by excessive osteoclast bone resorption leading to increased skeletal fragility and fracture risk. Multinucleated osteoclasts formed through the fusion of mononuclear precursors are the principle cell capable of bone resorption. Pregnenolone (Preg) is the gra...