Notopterol Attenuates Estrogen Deficiency-Induced Osteoporosis via Repressing RANKL Signaling and Reactive Oxygen Species

• Main Authors: Delong Chen (Author), Qingqing Wang (Author), Ying Li (Author), Ping Sun (Author), Vincent Kuek (Author), Jinbo Yuan (Author), Junzheng Yang (Author), Longfei Wen (Author), Haibin Wang (Author), Jiake Xu (Author), Peng Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integrity of the skeleton is sustained through the balanced activities of osteoblasts and osteoclasts in bone remodeling unit. The balance can be disrupted by excessive osteoclasts activation commonly seen in osteoporosis. Notopterol (NOT) is a main component of Notopterygium incisum which exerts a...