New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

• Үндсэн зохиолчид: Hamada H. H. Mohammed (Зохиогч), Amer Ali Abd El-Hafeez (Зохиогч), Kareem Ebeid (Зохиогч), Aml I. Mekkawy (Зохиогч), Mohammed A. S. Abourehab (Зохиогч), Emad I. Wafa (Зохиогч), Suhaila O. Alhaj-Suliman (Зохиогч), Aliasger K. Salem (Зохиогч), Pradipta Ghosh (Зохиогч), Gamal El-Din A (Зохиогч), Alaa M. Hayallah (Зохиогч), Samar H. Abbas (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67-62.47 µM, and 4.19-24.37 µM fo...