New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

• Главные авторы: Hamada H. H. Mohammed (Автор), Amer Ali Abd El-Hafeez (Автор), Kareem Ebeid (Автор), Aml I. Mekkawy (Автор), Mohammed A. S. Abourehab (Автор), Emad I. Wafa (Автор), Suhaila O. Alhaj-Suliman (Автор), Aliasger K. Salem (Автор), Pradipta Ghosh (Автор), Gamal El-Din A (Автор), Alaa M. Hayallah (Автор), Samar H. Abbas (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67-62.47 µM, and 4.19-24.37 µM fo...