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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67-62.47 µM, and 4.19-24.37 µM fo...

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Main Authors:	Hamada H. H. Mohammed (Author), Amer Ali Abd El-Hafeez (Author), Kareem Ebeid (Author), Aml I. Mekkawy (Author), Mohammed A. S. Abourehab (Author), Emad I. Wafa (Author), Suhaila O. Alhaj-Suliman (Author), Aliasger K. Salem (Author), Pradipta Ghosh (Author), Gamal El-Din A (Author), Alaa M. Hayallah (Author), Samar H. Abbas (Author)
Format:	Book
Published:	Taylor & Francis Group, 2022-12-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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