Image de couverture de livre

New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti-proliferative activity against colon cancer cells. Compounds 4a-j displayed IC50s ranged from 2.53-8.67 µM, 8.67-62.47 µM, and 4.19-24.37 µM fo...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Hamada H. H. Mohammed (Auteur), Amer Ali Abd El-Hafeez (Auteur), Kareem Ebeid (Auteur), Aml I. Mekkawy (Auteur), Mohammed A. S. Abourehab (Auteur), Emad I. Wafa (Auteur), Suhaila O. Alhaj-Suliman (Auteur), Aliasger K. Salem (Auteur), Pradipta Ghosh (Auteur), Gamal El-Din A (Auteur), Alaa M. Hayallah (Auteur), Samar H. Abbas (Auteur)
Format:	Livre
Publié:	Taylor & Francis Group, 2022-12-01T00:00:00Z.
Sujets:	article
Accès en ligne:	Connect to this object online.
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors
par: Wenjing Liu, et autres
Publié: (2022)

Synthesis of New Thiazole-Privileged Chalcones as Tubulin Polymerization Inhibitors with Potential Anticancer Activities
par: Hamada Hashem, et autres
Publié: (2024)

Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors
par: Md. Jahangir Alam, et autres
Publié: (2022)

Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines
par: Kanyani Sangpheak, et autres
Publié: (2019)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
par: Lamya H. Al-Wahaibi, et autres
Publié: (2021)

Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme
par: Hadeer K. Swedan, et autres
Publié: (2023)

Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors
par: Gehan A. Abdel-Hafez, et autres
Publié: (2022)

Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity
par: Mourad AAE, et autres
Publié: (2020)

The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria.
par: Gaber El-Saber Batiha, et autres
Publié: (2019)

Evaluation of Resistance to Ciprofloxacin and Identification of Mutations in Topoisomerase Genes in Escherichia coli and Klebsiella pneumonia Isolated from Pediatric Urinary Tract Infections
par: Keyghobad Ghadiri, et autres
Publié: (2019)

Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles
par: Soufyane Hba, et autres
Publié: (2023)

Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site
par: Guangcheng Wang, et autres
Publié: (2020)

Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors
par: Riham I. Ahmed, et autres
Publié: (2017)

Role of different biodegradable polymers on the permeability of ciprofloxacin
par: Chandra Kanti Chakraborti, et autres
Publié: (2014)

Synthesis and Study of Many New Chalcone Derivatives
par: Natiq G. Ahmad, et autres
Publié: (2018)

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
par: Nisha Abdul Rehuman, et autres
Publié: (2022)

In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II
par: Mohamed Badr, et autres
Publié: (2024)

New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies
par: Asmaa H. Mohamed, et autres
Publié: (2024)

The Search for New Antibacterial Agents among 1,2,3-Triazole Functionalized Ciprofloxacin and Norfloxacin Hybrids: Synthesis, Docking Studies, and Biological Activity Evaluation
par: Halyna Hryhoriv, et autres
Publié: (2021)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
par: Scott Grossman, et autres
Publié: (2023)

Tubulin/microtubules as novel clozapine targets
par: Mizuki Hino, et autres
Publié: (2022)

Effect of safranal on the response of cancer cells to topoisomerase I inhibitors: Does sequence matter?
par: Lama Lozon, et autres
Publié: (2022)

Fabrication and application of targeted ciprofloxacin nanocarriers for the treatment of chronic bacterial prostatitis
par: Sahar I. Mohammad, et autres
Publié: (2024)

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies
par: Faten Farouk, et autres
Publié: (2023)

New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors
par: Momen R. Fareed, et autres
Publié: (2021)

Quantitative assay for ciprofloxacin and enrofloxacin formulations
par: Saundria Moed, et autres
Publié: (2019)

Synthesis and Characterization of New 5-Fluoroisatin-Chalcone Conjugates with Expected Antimicrobial Activity
par: Hamza Fadhil Hamza, et autres
Publié: (2024)

Solulan C24- and Bile Salts-Modified Niosomes for New Ciprofloxacin Mannich Base for Combatting Pseudomonas-Infected Corneal Ulcer in Rabbits
par: Soad A. Mohamed, et autres
Publié: (2021)

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
par: Mona S. El-Zoghbi, et autres
Publié: (2023)

Chitosan Nanoparticles for Meloxicam Ocular Delivery: Development, In Vitro Characterization, and In Vivo Evaluation in a Rabbit Eye Model
par: Hebatallah B. Mohamed, et autres
Publié: (2022)

Recent developments in topoisomerase-targeted cancer chemotherapy
par: KirkE. Hevener, et autres
Publié: (2018)

Mechanisms regulating resistance to inhibitors of topoisomerase II
par: Ram N. Ganapathi, et autres
Publié: (2013)

DNA topoisomerases as molecular targets for anticancer drugs
par: Kamila Buzun, et autres
Publié: (2020)

Novel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies
par: Alghamdi SS, et autres
Publié: (2021)

Synthesis of some substituted pyrimidines via cycloaddition reaction of amidines and chalcones
par: H. M. Al-Ajely, et autres
Publié: (2009)

Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives
par: Mhaidat NM, et autres
Publié: (2015)

Ciprofloxacin-Induced Antibacterial Activity Is Attenuated by Phosphodiesterase Inhibitors
par: Majed M. Masadeh, PhD, et autres
Publié: (2015)

Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity
par: Dong-Jun Fu, et autres
Publié: (2023)

Genetic Variation of the -tubulin Gene of Babesia caballi Strains
par: María Guadalupe Montes-Cortés, et autres
Publié: (2017)

Novel Thiazolidine-2,4-dione-trimethoxybenzene-thiazole Hybrids as Human Topoisomerases Inhibitors
par: Maria Stefania Sinicropi, et autres
Publié: (2023)