A Novel LC‐MS/MS Assay for Quantification of Des‐carboxy Prothrombin and Characterization of Warfarin‐Induced Changes

• Main Authors: Abdul Basit (Author), Bhagwat Prasad (Author), Joanne K. Estergreen (Author), Daniel E. Sabath (Author), Nathan Alade (Author), David L. Veenstra (Author), Allan E. Rettie (Author), Kenneth E. Thummel (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2020-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Warfarin is a narrow therapeutic index anticoagulant drug and its use is associated with infrequent but significant adverse bleeding events. The international normalized ratio (INR) is the most commonly used biomarker to monitor and titrate warfarin therapy. However, INR is derived from a functional...