Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa

• Main Authors: Yu-Wei Lin (Author), Mei-Ling Han (Author), Jinxin Zhao (Author), Yan Zhu (Author), Gauri Rao (Author), Alan Forrest (Author), Jiangning Song (Author), Keith S. Kaye (Author), Paul Hertzog (Author), Anthony Purcell (Author), Darren Creek (Author), Qi Tony Zhou (Author), Tony Velkov (Author), Jian Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymyxins are used as a last-resort class of antibiotics against multidrug-resistant (MDR) Gram-negative Pseudomonas aeruginosa. As polymyxin monotherapy is associated with potential development of resistance, combination therapy is highly recommended. This study investigated the mechanism underlyi...