Monitoring Tacrolimus Concentrations in Whole Blood and Peripheral Blood Mononuclear Cells: Inter- and Intra-Patient Variability in a Cohort of Pediatric Patients

• Main Authors: Amedeo De Nicolò (Author), Michele Pinon (Author), Alice Palermiti (Author), Antonello Nonnato (Author), Alessandra Manca (Author), Jacopo Mula (Author), Silvia Catalano (Author), Francesco Tandoi (Author), Renato Romagnoli (Author), Antonio D'Avolio (Author), Pier Luigi Calvo (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Fag: article
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Tacrolimus (TAC) is a first-choice immunosuppressant for solid organ transplantation, characterized by high potential for drug-drug interactions, significant inter- and intra-patient variability, and narrow therapeutic index. Therapeutic drug monitoring (TDM) of TAC concentrations in whole blood (WB...