Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

• Main Authors: Wenjing Liu (Author), Lei Peng (Author), Wanli Tian (Author), Yi Li (Author), Ping Zhang (Author), Kuanxiang Sun (Author), Yeming Yang (Author), Xiao Li (Author), Guisen Li (Author), Xianjun Zhu (Author)
• Format: Book
• Published: The Company of Biologists, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the β-subunit TMEM30A. Podocytes in the glomerulus form a filtration barrier to prevent the traversing of large cellula...