Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug

• Main Authors: Xin Wang (Author), Chang Li (Author), Na Fan (Author), Jing Li (Author), Haotian Zhang (Author), Lei Shang (Author), Zhonggui He (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present paper, chiral mesoporous silica nano-cocoon (A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin (IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, A-CMSN possessed 2D hexagonal nano-c...