Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis

• Glavni autori: Juan Zhang (Autor), Yeye Ma (Autor), Yue Zhang (Autor), Sijia Niu (Autor), Maolin Chu (Autor), Zhiyi Zhang (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Angiogenesis is a crucial event in the pathogenesis of rheumatoid arthritis (RA). Arsenic trioxide (ATO, As2O3) has been reported to inhibit synovial angiogenesis via the vascular endothelial growth factor (VEGF)-centered functional module. However, the exact mechanisms of ATO on VEGF modulation rem...