The anti-influenza drug oseltamivir evokes hypothermia in mice through dopamine D2 receptor activation via central actions

• Main Authors: Akihiro Fukushima (Author), Arisa Fukui (Author), Yuki Takemura (Author), Yasuhiro Maeda (Author), Hideki Ono (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oseltamivir has a hypothermic effect in mice when injected intraperitoneally (i.p.) and intracerebroventricularly (i.c.v.). Here we show that the hypothermia evoked by i.c.v.-oseltamivir is inhibited by non-selective dopamine receptor antagonists (sulpiride and haloperidol) and the D2-selective anta...