Enhanced Stability and Bioactivity of Natural Anticancer Topoisomerase I Inhibitors through Cyclodextrin Complexation

• Main Authors: Víctor González-Ruiz (Author), Ángel Cores (Author), Olmo Martín-Cámara (Author), Karen Orellana (Author), Víctor Cervera-Carrascón (Author), Patrycja Michalska (Author), Ana I. Olives (Author), Rafael León (Author), M. Antonia Martín (Author), J. Carlos Menéndez (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of cyclodextrins as drug nano-carrier systems for drug delivery is gaining importance in the pharmaceutical industry due to the interesting pharmacokinetic properties of the resulting inclusion complexes. In the present work, complexes of the anti-cancer alkaloids camptothecin and luotonin A...