2H-chromene and 7H-furo-chromene derivatives selectively inhibit tumour associated human carbonic anhydrase IX and XII isoforms

• Main Authors: Lisa Sequeira (Author), Simona Distinto (Author), Rita Meleddu (Author), Marco Gaspari (Author), Andrea Angeli (Author), Filippo Cottiglia (Author), Daniela Secci (Author), Alessia Onali (Author), Erica Sanna (Author), Fernanda Borges (Author), Eugenio Uriarte (Author), Stefano Alcaro (Author), Claudiu T. Supuran (Author), Elias Maccioni (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumour associated carbonic anhydrases (CAs) IX and XII have been recognised as potential targets for the treatment of hypoxic tumours. Therefore, considering the high pharmacological potential of the chromene scaffold as selective ligand of the IX and XII isoforms, two libraries of compounds, namely...