Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response

• Main Authors: Nikolay V. Ogryzko (Author), Emily E. Hoggett (Author), Sara Solaymani-Kohal (Author), Simon Tazzyman (Author), Timothy J. A. Chico (Author), Stephen A. Renshaw (Author), Heather L. Wilson (Author)
• Format: Book
• Published: The Company of Biologists, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-1 (IL-1), the 'gatekeeper' of inflammation, is the apical cytokine in a signalling cascade that drives the early response to injury or infection. Expression, processing and secretion of IL-1 are tightly controlled, and dysregulated IL-1 signalling has been implicated in a numbe...