Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling

• Κύριοι συγγραφείς: Xin Zhuo (Συγγραφέας), Yue Wu (Συγγραφέας), Xiujuan Fu (Συγγραφέας), Jianbin Li (Συγγραφέας), Yuxin Xiang (Συγγραφέας), Xiaoyu Liang (Συγγραφέας), Canquan Mao (Συγγραφέας), Yuhong Jiang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2024-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases, immune cell infiltration and protease-driven tissue damages. It is an urgent need to explore potential drug strategies for mitigating lung inf...