Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency

• Main Authors: Zheng Li (Author), Muxin Yue (Author), Boon Chin Heng (Author), Yunsong Liu (Author), Ping Zhang (Author), Yongsheng Zhou (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract As an important enzyme for gluconeogenesis, mitochondrial phosphoenolpyruvate carboxykinase (PCK2) has further complex functions beyond regulation of glucose metabolism. Here, we report that conditional knockout of Pck2 in osteoblasts results in a pathological phenotype manifested as cranio...