PK/PD Modeling of the PDE7 Inhibitor-GRMS-55 in a Mouse Model of Autoimmune Hepatitis

• Asıl Yazarlar: Artur Świerczek (Yazar), Hanna Plutecka (Yazar), Marietta Ślusarczyk (Yazar), Grażyna Chłoń-Rzepa (Yazar), Elżbieta Wyska (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

This study aimed to assess the efficacy and explore the mechanisms of action of a potent phosphodiesterase (PDE)7A and a moderate PDE4B inhibitor GRMS-55 in a mouse model of autoimmune hepatitis (AIH). The concentrations of GRMS-55 and relevant biomarkers were measured in the serum of BALB/c mice wi...