DNA Methylation‐Based Epigenetic Repression of SLC22A4 Promotes Resistance to Cytarabine in Acute Myeloid Leukemia

• Main Authors: Daelynn R. Buelow (Author), Jason T. Anderson (Author), Stanley B. Pounds (Author), Lei Shi (Author), Jatinder K. Lamba (Author), Shuiying Hu (Author), Alice A. Gibson (Author), Emily A. Goodwin (Author), Alex Sparreboom (Author), Sharyn D. Baker (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reduced expression of the uptake transporter, OCTN1 (SLC22A4), has been reported as a strong predictor of poor event‐free and overall survival in multiple cohorts of patients with acute myeloid leukemia (AML) receiving the cytidine nucleoside analog, cytarabine (Ara‐C). To further understand the mec...