1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase

• Main Authors: Yanlin Jian (Author), Martijn D. P. Risseeuw (Author), Mathy Froeyen (Author), Lijun Song (Author), Davie Cappoen (Author), Paul Cos (Author), Hélène Munier-Lehmann (Author), Serge van Calenbergh (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of readily accessible 1-(piperidin-3-yl)thymine amides was designed, synthesised and evaluated as Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors. In line with the modelling results, most inhibitors showed reasonable MtbTMPK inhibitory activity. Compounds 4b and 4i were slightly more p...