Pinostrobin and Tectochrysin Conquer Multidrug-Resistant Cancer Cells via Inhibiting P-Glycoprotein ATPase

• Egile Nagusiak: I-Ting Wu (Egilea), Chan-Yen Kuo (Egilea), Ching-Hui Su (Egilea), Yu-Hsuan Lan (Egilea), Chin-Chuan Hung (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Enhanced drug efflux through ATP-binding cassette transporters, particularly P-glycoprotein (P-gp), is a key mechanism underlying multidrug resistance (MDR). In the present study, we investigated the inhibitory effects of pinostrobin and tectochrysin on P-gp in MDR cancer cells and the underlying me...