Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α-Ve-Cadherin Pathway

• Main Authors: Daniel Rand (Author), Orly Ravid (Author), Dana Atrakchi (Author), Hila Israelov (Author), Yael Bresler (Author), Chen Shemesh (Author), Liora Omesi (Author), Sigal Liraz-Zaltsman (Author), Fabien Gosselet (Author), Taber S. Maskrey (Author), Michal Schnaider Beeri (Author), Peter Wipf (Author), Itzik Cooper (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to investigate the molecular response to damage at the blood-brain barrier (BBB) and to elucidate critical pathways that might lead to effective treatment in central nervous system (CNS) pathologies in which the BBB is compromised. We have used a human, stem-cell deri...