Determining the Anticancer Activity of Sphingosine Kinase Inhibitors Containing Heteroatoms in Their Tail Structure

• Päätekijät: Jitendra Shrestha (Tekijä), Seong Woong Kim (Tekijä), Su-Bin Kim (Tekijä), Yoon Sin Oh (Tekijä), Sung Hwan Ki (Tekijä), Taeho Lee (Tekijä), Sang-Bum Kim (Tekijä), Taeuk Park (Tekijä), Dong Jae Baek (Tekijä), Eun-Young Park (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Sphingosine kinase (SK) enzyme, a central player of sphingolipid rheostat, catalyzes the phosphorylation of sphingosine to the bioactive lipid mediator sphingosine 1 phosphate (S1P), which regulates cancer cell proliferation, migration, differentiation, and angiogenesis through its extracellular fiv...