Determining the Anticancer Activity of Sphingosine Kinase Inhibitors Containing Heteroatoms in Their Tail Structure

• Main Authors: Jitendra Shrestha (Author), Seong Woong Kim (Author), Su-Bin Kim (Author), Yoon Sin Oh (Author), Sung Hwan Ki (Author), Taeho Lee (Author), Sang-Bum Kim (Author), Taeuk Park (Author), Dong Jae Baek (Author), Eun-Young Park (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sphingosine kinase (SK) enzyme, a central player of sphingolipid rheostat, catalyzes the phosphorylation of sphingosine to the bioactive lipid mediator sphingosine 1 phosphate (S1P), which regulates cancer cell proliferation, migration, differentiation, and angiogenesis through its extracellular fiv...