A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans.

• Main Authors: Mariana L Coutinho (Author), Henry A Choy (Author), Melissa M Kelley (Author), James Matsunaga (Author), Jane T Babbitt (Author), Michael S Lewis (Author), Jose Antonio G Aleixo (Author), David A Haake (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determ...