Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2

• Main Authors: Xiufang Chen (Author), Qian Zhou (Author), Huamin Chen (Author), Juan Bai (Author), Ruike An (Author), Keyi Zhang (Author), Xinyue Zhang (Author), Hui An (Author), Jitai Zhang (Author), Yongyu Wang (Author), Ming Li (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutathione (GSH), a robust endogenous antioxidant, actively participates in the modulation of the redox status of cysteine residues in proteins. Previous studies have indicated that GSH can prevent β-cell failure and prediabetes caused by chronic oscillating glucose (OsG) administration. However, t...