Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer

• Main Authors: Yuanyuan Zhang (Author), Lei zhang (Author), Hongru Sun (Author), Ying Liu (Author), Jing Xu (Author), Hao Huang (Author), Jinming Fu (Author), Ding Zhang (Author), Tian Tian (Author), Yashuang Zhao (Author), Guiyu Wang (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Changes in DNA methylation of immunosuppressive checkpoints may impact express and consequently affect antigen processing and presentation by tumor cells and facilitates evasion of immunosurveillance and lead to colorectal cancer (CRC). This study is to investigate the effect of...