Targeting Th17 Cells with Small Molecules and Small Interference RNA

• Autores principales: Hui Lin (Autor), Pingfang Song (Autor), Yi Zhao (Autor), Li-Jia Xue (Autor), Yi Liu (Autor), Cong-Qiu Chu (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2015-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

T helper 17 (Th17) cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL-) 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn...