Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy

• Main Authors: Yongchun Pan (Author), Xiaowei Luan (Author), Fei Zeng (Author), Xuyuan Wang (Author), Shurong Qin (Author), Qianglan Lu (Author), Guanzhong He (Author), Yanfeng Gao (Author), Xiaolian Sun (Author), Xin Han (Author), Bangshun He (Author), Yujun Song (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies. However, the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression. Here, we...