Mitochondrial <i>Glrx2</i> Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice

• Main Authors: Jing Li (Author), Xuewen Tang (Author), Xing Wen (Author), Xiaoyuan Ren (Author), Huihui Zhang (Author), Yatao Du (Author), Jun Lu (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) is one of the most widely used drugs with antipyretic and analgesic effects, and thus hepatotoxicity from the overdose of APAP becomes one of the most common forms of drug-induced liver injury. The reaction towards thiol molecules, such as GSH by APAP metabolite, <i>N</...