Evaluation of the abuse potential of difelikefalin, a selective kappa‐opioid receptor agonist, in recreational polydrug users

• Main Authors: Megan J. Shram (Author), Robert H. Spencer (Author), Jenny Qian (Author), Catherine L. Munera (Author), Michael E. Lewis (Author), Jack E. Henningfield (Author), Lynn Webster (Author), Frédérique Menzaghi (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Difelikefalin, a selective kappa‐opioid receptor agonist with limited central nervous system penetration, is being developed for the treatment of chronic pruritic conditions. This randomized, double‐blind, active‐ and placebo‐controlled, four‐way crossover study was designed to evaluate the...