Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

• Main Authors: Xia Hu (Author), Zhao-Lan Hu (Author), Zheng Li (Author), Chun-Sheng Ruan (Author), Wen-Ying Qiu (Author), Aihua Pan (Author), Chang-Qi Li (Author), Yan Cai (Author), Lu Shen (Author), Yaping Chu (Author), Bei-Sha Tang (Author), Huaibin Cai (Author), Xin-Fu Zhou (Author), Chao Ma (Author), Xiao-Xin Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum. Sortilin changes were characterized in p...