Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes

• Main Authors: Silvia Bua (Author), Emanuela Berrino (Author), Sonia Del Prete (Author), Vallabhaneni S. Murthy (Author), Vijayaparthasarathi Vijayakumar (Author), Yasinalli Tamboli (Author), Clemente Capasso (Author), Elisabetta Cerbai (Author), Alessandro Mugelli (Author), Fabrizio Carta (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis of a new series of sulfamides incorporating ortho-, meta, and para-benzenesulfamide moieties is reported, which were investigated for the inhibition of two human (h) isoforms of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I and II, and two Vibrio cholerae enzymes, belongin...