Mannose-Functionalized Isoniazid-Loaded Nanostructured Lipid Carriers for Pulmonary Delivery: In Vitro Prospects and In Vivo Therapeutic Efficacy Assessment

• Main Authors: Shaveta Ahalwat (Author), Dinesh Chandra Bhatt (Author), Surbhi Rohilla (Author), Vikas Jogpal (Author), Kirti Sharma (Author), Tarun Virmani (Author), Girish Kumar (Author), Abdulsalam Alhalmi (Author), Ali S. Alqahtani (Author), Omar M. Noman (Author), Marwan Almoiliqy (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resistance to isoniazid (INH) is common and increases the possibility of acquiring multidrug-resistant tuberculosis. For this study, isoniazid-loaded nanostructured lipid carriers (INH-NLCs) were developed and effectively functionalized with mannose (Man) to enhance the residence time of the drug wi...