Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors

• Main Authors: Keli Zong (Author), Wei Li (Author), Yijie Xu (Author), Xu Zhao (Author), Ruiyuan Cao (Author), Hong Yan (Author), Xingzhou Li (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) is a major mosquito-borne human pathogen in tropical countries; however, there are currently no targeted antiviral treatments for DENV infection. Compounds <b>27</b> and <b>29</b> have been reported to be allosteric inhibitors of DENV RdRp with potent inhi...