2-Aminophenoxazine-3-one Prevents Pulmonary Metastasis of Mouse B16 Melanoma Cells in Mice

2-Aminophenoxazine-3-one Prevents Pulmonary Metastasis of Mouse B16 Melanoma Cells in Mice

2-Aminophenoxazine-3-one (Phx-3) induced cellular apoptosis in mouse melanoma B16 cells as detected by DNA laddering and upregulated Fas expression in the cells in vitro. Next, the anti-metastatic effects of Phx-3 were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail...

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Main Authors: Takayuki Hongo (Author), Naoko Miyano-Kurosaki (Author), Kunihiko Kurosaki (Author), Akihiro Hata (Author), Satoko Harigae (Author), Akio Tomoda (Author)
Format: Book
Published: Elsevier, 2010-01-01T00:00:00Z.
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