Selumetinib - a potential small molecule inhibitor for osteoarthritis treatment

• Main Authors: Xiaohang Zheng (Author), Jianxin Qiu (Author), Wenjun Pan (Author), Yuhang Gong (Author), Weikang Zhang (Author), Ting Jiang (Author), Lihua Chen (Author), Weifu Chen (Author), Zhenghua Hong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Osteoarthritis (OA) is a common disease that mainly manifests as inflammation and destruction of cartilage and subchondral bone. Recently, necroptosis has been reported to play an important role in the development of OA. Selumetinib displays a contrasting expression pattern to necroptosi...