A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles

• Main Authors: Hafiz Akbar Ali (Author), Yalan Li (Author), Akram Hafiz Muhammad Bilal (Author), Tingting Qin (Author), Ziqiao Yuan (Author), Wen Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic modifications, specifically acetylation of histone plays a decisive role in gene regulation and transcription of normal cellular mechanisms and pathological conditions. The bromodomain and extraterminal (BET) proteins (BRD2, BRD3, BRD4, and BRDT), being epigenetic readers, ligate to acety...