Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression

• Main Authors: Nicola Morrice (Author), Susanne Vainio (Author), Kirsi Mikkola (Author), Lidy van Aalten (Author), Jennifer R. Gallagher (Author), Michael L.J. Ashford (Author), Alison D. McNeilly (Author), Rory J. McCrimmon (Author), Alexandra Grosfeld (Author), Patricia Serradas (Author), Jukka Koffert (Author), Ewan R. Pearson (Author), Pirjo Nuutila (Author), Calum Sutherland (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Metformin is the first line therapy recommended for type 2 diabetes. However, the precise mechanism of action remains unclear and up to a quarter of patients show some degree of intolerance to the drug, with a similar number showing poor response to treatment, limiting its effectiveness....