Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression

• Main Authors: Manoela Viar Fogaça (Author), Priscila de Matos Cândido-Bacani (Author), Lucas Milanez Benicio (Author), Lara Martinelli Zapata (Author), Priscilla de Freitas Cardoso (Author), Marcelo Tempesta de Oliveira (Author), Tamara Regina Calvo (Author), Eliana Aparecida Varanda (Author), Wagner Vilegas (Author), Ilce Mara de Syllos Cólus (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: Indigofera suffruticosa Miller (Fabaceae) and I. truxillensis Kunth produce compounds, such as isatin (ISA) and indirubin (IRN), which possess antitumour properties. Their effects in mammalian cells are still not very well understood. Objective: We evaluated the activities of ISA and/or IRN...