Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases

• Main Authors: Jiuping Zeng (Author), Mingxing Li (Author), Qianyun Zhao (Author), Meijuan Chen (Author), Long Zhao (Author), Shulin Wei (Author), Huan Yang (Author), Yueshui Zhao (Author), Anqi Wang (Author), Jing Shen (Author), Fukuan Du (Author), Yu Chen (Author), Shuai Deng (Author), Fang Wang (Author), Zhuo Zhang (Author), Zhi Li (Author), Tiangang Wang (Author), Shengpeng Wang (Author), Zhangang Xiao (Author), Xu Wu (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt) that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a critical role in the progression of several inflammatory and autoimmune conditions. An emerging novel approach to...