Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

• Main Authors: Laurynas Mockeliunas (Author), Lina Keutzer (Author), Marieke G. G. Sturkenboom (Author), Mathieu S. Bolhuis (Author), Lotte M. G. Hulskotte (Author), Onno W. Akkerman (Author), Ulrika S. H. Simonsson (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Linezolid is an efficacious medication for the treatment of drug-resistant tuberculosis but has been associated with serious safety issues that can result in treatment interruption. The objectives of this study were thus to build a population pharmacokinetic model and to use the developed model to e...