Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder

• Main Authors: Caroline W. Grant (Author), Angelina R. Wilton (Author), Rima Kaddurah-Daouk (Author), Michelle Skime (Author), Joanna Biernacka (Author), Taryn Mayes (Author), Thomas Carmody (Author), Liewei Wang (Author), Konstantinos Lazaridis (Author), Richard Weinshilboum (Author), William V. Bobo (Author), Madhukar H. Trivedi (Author), Paul E. Croarkin (Author), Arjun P. Athreya (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Individuals with major depressive disorder (MDD) and a lifetime history of attempted suicide demonstrate lower antidepressant response rates than those without a prior suicide attempt. Identifying biomarkers of antidepressant response and lifetime history of attempted suicide may help au...