Design, synthesis and biological evaluation of substituted pyrazoles endowed with brominated 4-methyl 7-hydroxy coumarin as new scaffolds against Alzheimer's disease

• Main Authors: Siju Ellickal Narayanan (Author), Hariraj Narayanan (Author), Minil Mukundan (Author), Saranya Balan (Author), C. P. Vishnupriya (Author), Adarsh Gopinathan (Author), Rajalekshmi Ganesan Rajamma (Author), Akash Marathakam (Author)
• Format: Book
• Published: SpringerOpen, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The study aimed to design, synthesize and evaluate various brominated derivatives of 7-hydroxy coumarin as a new scaffold against Alzheimer's disease by in vivo and in vitro models. A group of three novel pyrazoles endowed with brominated 7-hydroxy 4-methyl coumarin derivati...