Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases

• Автори: Martina Hrast (Автор), Kaja Rožman (Автор), Iza Ogris (Автор), Veronika Škedelj (Автор), Delphine Patin (Автор), Matej Sova (Автор), Hélène Barreteau (Автор), Stanislav Gobec (Автор), Simona Golič Grdadolnik (Автор), Anamarija Zega (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore represent interesting targets for antibacterial drug discovery. MurC, D, E and F are all ATP-dependent ligases. Accordingly, with the aim being to...