Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases

• Main Authors: Martina Hrast (Author), Kaja Rožman (Author), Iza Ogris (Author), Veronika Škedelj (Author), Delphine Patin (Author), Matej Sova (Author), Hélène Barreteau (Author), Stanislav Gobec (Author), Simona Golič Grdadolnik (Author), Anamarija Zega (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore represent interesting targets for antibacterial drug discovery. MurC, D, E and F are all ATP-dependent ligases. Accordingly, with the aim being to...