C/D box snoRNA SNORD113-6 guides 2'-O-methylation and protects against site-specific fragmentation of tRNALeu(TAA) in vascular remodeling

• Main Authors: Eva van Ingen (Author), Pleun A.M. Engbers (Author), Tamar Woudenberg (Author), M. Leontien van der Bent (Author), Hailiang Mei (Author), Johann Wojta (Author), Paul H.A. Quax (Author), A. Yaël Nossent (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

C/D box small nucleolar RNAs (snoRNAs) of the DLK1-DIO3 locus are associated with vascular remodeling and cardiovascular disease. None of these snoRNAs has any known targets yet except for one, AF357425/SNORD113-6. We previously showed that this snoRNA targets mRNAs of the integrin signaling pathway...